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. 2021 Jul 11;22(14):7431. doi: 10.3390/ijms22147431

Figure 1.

Figure 1

PSMA and AR in 22Rv1, C4-2, and LNCaP prostate cancer cell lines by PET and IHC. (A) Exemplary 68Ga-PSMA-11-PET/CT maximum intensity projection (MIP) images of NOD/Scid mice bearing tumors (white arrows) of 22Rv1, C4-2, or LNCaP cell lines. Average tumor uptake (%IA/g) per gram tissue is stated below the image. (B) Representative images of PSMA IHC and bar plots for % positivity (mean ± SD, n = 3). (C) Representative images of AR IHC and bar plots for % positivity (mean ± SD, n = 3). Scale = 20 µm. Abbreviations: PSMA, prostate-specific membrane antigen; %IA/g, % injected activity per gram tissue; AR, androgen receptor. Statistics: ordinary one-way ANOVA with Sidak’s multiple comparisons test; **** p ≤ 0.0001; ns = non significant.