Table 3.
Inhibitory potency of DPKs to α-glucosidase and PTP1B.
| Compd. | α-glucosidase
(IC50/μM) |
PTP1B (Inhibition Ratio/%) a | Compd. | α-glucosidase (IC50/μM) |
PTP1B (Inhibition Ratio/%) a |
|---|---|---|---|---|---|
| 1 | 18.2 | 29 | 10 | 40.7 | <10 |
| 2 | 130.7 | <10 | 11 | 37.5 | <10 |
| 3 | 83.9 | <10 | 12 | 1086.6 | <10 |
| 4 | 144.2 | <10 | 13 | 480.5 | <10 |
| 5 | 1093.5 | <10 | 14 | 353.2 | <10 |
| 6 | 267.3 | <10 | 15 | 67.8 | <10 |
| 7 | 198.2 | <10 | 16 | 362.6 | <10 |
| 8 | 364.3 | <10 | Acarbose b | 408.0 | - |
| 9 | 7.6 | <10 | Oleanolic acid c | - | 99.1 |
a The inhibition ratio screening concentration was 100 μg/mL for the PTP1B test; b Acarbose was used as a positive control for the α-glucosidase inhibitory test; c Oleanolic acid was used as a positive control for PTP1B inhibitory test.