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. 2021 Jul 17;26(14):4330. doi: 10.3390/molecules26144330

Figure 6.

Figure 6

The potential mechanism of action of miR-145 and miR-210 in cancer cells. PI3k/AKT signaling is often constitutively activated in cancer. Inactivation of FOXO1 and subsequent inhibition of miR-145 expression by the PI3K/AKT pathway favors cell survival, proliferation, and expansion of the CSC population and increases self-renewal and tumorigenic capacity. Activation of STAT3 induces cancer cell survival by inducing the expression of c-Myc. miR-210 inhibits SOCS1 and activates the STAT3 pathway favoring cell survival.