Table 3.
Kyoto Encyclopedia of Genes and Genomes (KEGGS) and The Reactome pathways enriched in NCAM2 interactome.
| KEGGs Enrichment | ||
|---|---|---|
| KEGG | Term Description | Proteins |
| mmu04722 | Neurotrophin signaling pathway | Calm1,Camk2a,Camk2b,Camk2d,Camk2g,Ywhae |
| mmu04720 | Long-term potentiation | Calm1,Camk2a,Camk2b,Camk2d,Camk2g |
| mmu04012 | ErbB signaling pathway | Camk2a,Camk2b,Camk2d,Camk2g |
| mmu04540 | Gap junction | Tuba1a,Tuba1c,Tubb4a,Tubb6 |
| mmu04020 | Calcium signaling pathway | Calm1,Camk2a,Camk2b,Camk2d,Camk2g |
| mmu04024 | cAMP signaling pathway | Calm1,Camk2a,Camk2b,Camk2d,Camk2g |
| mmu04360 | Axon guidance | Camk2a,Camk2b,Camk2d,Camk2g |
| Reactome pathways enriched | ||
| Reactome | Term Description | Proteins |
| MMU-195258 | RHO GTPase Effectors | Actb,Calm1,Dynll1,Dynll2,Myl6,Tuba1a,Tuba1c,Tubb4a, Tubb6,Ywhae,Ywhag,Ywhaz |
| MMU-442729 | CREB phosphorylation through the activation of CaMKII | Calm1,Camk2a,Camk2b,Camk2d,Camk2g,Nefl |
| MMU-442982 | Ras activation upon Ca2+ influx through NMDA receptor | Calm1,Camk2a,Camk2b,Camk2d,Camk2g,Nefl |
| MMU-199991 | Membrane Trafficking | Actb,Capza2,Capzb,Dynll1,Dynll2,Rab33a,Tuba1a,Tuba1c, Tubb4a,Tubb6,Ywhae,Ywhag,Ywhaz |
| MMU-438066 | Unblocking of NMDA receptors, glutamate binding and activation | Camk2a,Camk2b,Camk2d,Camk2g,Nefl |
| MMU-5576892 | Phase 0-rapid depolarization | Calm1,Camk2a,Camk2b,Camk2d,Camk2g |
| MMU-190828 | Gap junction trafficking | Actb,Tuba1a,Tuba1c,Tubb4a,Tubb6 |
| MMU-190840 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | Tuba1a,Tuba1c,Tubb4a,Tubb6 |
| MMU-399719 | Trafficking of AMPA receptors | Camk2a,Camk2b,Camk2d,Camk2g |
| MMU-5673001 | RAF/MAP kinase cascade | Actb,Calm1,Camk2a,Camk2b,Camk2d,Camk2g,Nefl |
| MMU-1640170 | Cell Cycle | Dynll1,Dynll2,Tuba1a,Tuba1c,Tubb4a,Tubb6,Ywhae, Ywhag,Ywhaz |
| MMU-5620912 | Anchoring of the basal body to the plasma membrane | Dynll1,Tuba1a,Tubb4a,Ywhae,Ywhag |
List of the most relevant KEGGs and Reactome pathways enriched in NCAM2 interactome. The table presents the KEGGs or the Reactome pathways identifier, the term description and the list of proteins detected in the mass spectrometry for each specific item.