Figure 2.

Advantages and disadvantages of different DDS for cancer treatment. Lipid-based NPs reach high drug loading, but their half-life in blood limits their clinical translation; solid lipid NPs fails due to low drug loading and high accumulation; dendrimers are mainly toxic and difficult to scale their synthesis; metallic NPs are easily accumulated in the body and cause aggregation phenomena; MOFs and silica mesoporous NPs are not biodegradable and toxic; polymeric NPs are the most potential candidates for clinical translation due to their high biocompatibility and payload and surface modification flexibility.