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. 2021 Jul 14;13(14):3534. doi: 10.3390/cancers13143534

Figure 7.

Figure 7

IL-15-grown ARI2h BCMA-CARs produce lower amounts of pathology-related cytokines. UT or ARI2h-transduced (ARI2hIL-2, ARI2hIL-15, ARI2hIL-15/IL-7, ARI2hNone) T cells, or media (“ARP1 alone”), were co-cultured with ARP-1 cells for 6 h. (A) Heat map showing the relative secretion of a panel of cytokines and chemokines (shown on the right-hand side) as analyzed using a ProcartaPlex Multiplex Immunoassay kit (n = 4, UT, IL-2, IL-15 and IL-15/IL-7 groups; n = 2, “None” group). The relative abundance of each molecule in the analyzed supernatant is shown on a scale of blue (low) to red (high). (B–E) Individual quantification of TNFα (B), IL-9 (C), SDF-1α (D) and IL-22 (E) levels from panel A. * p < 0.05; ** p < 0.01; ns, not significant.