Figure 5.

Cell-type enrichment and analysis of changing levels of protein expression over time. (a) Expression Weighted Cell-type Enrichment performed using single cell RNAseq level 1 cell-type data obtained from [27], on the upregulated proteins at 12-moa. * p-value < 0.01. (b) Fold-change ratios are shown for all proteins regulated in at least one of the two datasets demonstrating their level of regulation over time. Proteins labeled with a + have been implicated in human AD in earlier reports, see Table S1. The top 10 most regulated proteins over time are highlighted in orange.