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. 2021 Jul 6;13(14):3393. doi: 10.3390/cancers13143393

Table 3.

The role of miRNAs in invasion and metastasis in vitro and in vivo.

MiRNA Target 1 Migration Invasion EMT Tumor Growth In Vivo Metastasis In Vivo Ref.
miR-1 PDE7A ↓ ↓ n/d n/d n/d [97]
miR-20a-5p STAT3 n/d ↓ ↓ n/d n/d [40]
miR-20b-5p H19 ↓ n/d n/d n/d n/d [116]
miR-22 ERα n/d ↓ n/d n/d n/d [121,156]
miR-23a SIX1 ↓ ↓ n/d ↓ n/d [128]
miR-23b MACC1 ↓ ↓ n/d ↓ n/d [137]
miR-26a EZH2 ↓ ↓ ↓ ↓ n/d [42]
miR-29a-5p TPX2 n/d ↓ n/d ↓ n/d [44]
miR-29b VEGFA, PTEN ↓ ↓ n/d ↓ ↓ [24,150]
miR-29c-3p KDM5B n/d ↓ n/d n/d n/d [154]
miR-30c MTA-1 ↓ ↓ n/d n/d n/d [96,173]
miR-34a Notch1, L1CAM, MMSET ↓ ↓ ↓ ↓ n/d [34,166,170]
miR-34b n/d ↓ ↓ n/d ↓ n/d [39,101]
miR-34c IL-6R ↓ ↓ n/d n/d n/d [43,123]
miR-99a AKT1, mTOR n/d ↓ n/d ↓ n/d [51]
miR-101 COX-2, EZH2, MCL-1, FOS, mTOR ↓ ↓ ↓ ↓ n/d [46,56,106,119]
miR-106b TWIST1 n/d ↓ ↓ n/d n/d [140]
miR-124 STAT3, IQGAP1, ITGB3 ↓ ↓ ↓ n/d n/d [33,50,167]
miR-125b ERBB2 n/d ↓ n/d n/d n/d [63,161]
miR-126 IRS1 ↓ ↓ n/d n/d n/d [109]
miR-129 GSK-3β ↓ ↓ n/d ↓ n/d [136]
miR-130b* ZEB1 n/d ↓ ↓ n/d n/d [32]
miR-133a PDE7A ↓ ↓ n/d n/d n/d [97]
miR-136 HMGA2 ↓ ↓ n/d n/d n/d [65]
miR-139-5p HOXA10 ↓ n/d n/d n/d n/d [54]
miR-142 CCND1 n/d n/d n/d ↓ n/d [69]
miR-143 MAPK1 ↓ ↓ n/d n/d n/d [22]
miR-144-3p EZH2 ↓ ↓ n/d n/d n/d [85]
miR-145 SOX11 ↓ ↓ n/d n/d n/d [21]
miR-148b DNMT1 ↓ ↓ n/d n/d ↓ [151]
miR-182 FOXO1 ↓ ↓ n/d n/d n/d [142,163]
miR-183-5p Ezrin ↓ ↓ ↓ n/d n/d [98]
miR-184 CDC25A n/d ↓ n/d n/d n/d [28]
miR-194 BMI-1, Sox3 ↓ ↓ ↓ ↓ ↓ [141,145]
miR-195 SOX4, GPER ↓ ↓ ↓ n/d n/d [108,139]
miR-196a n/d ↓ ↓ n/d n/d n/d [23]
miR-199a/b-5p FAM83B ↓ ↓ ↓ ↓ ↓ [93]
miR-200b TIMP2, PTEN, ZEB2 ↓ ↓ n/d n/d n/d [31,102,133]
miR-200c * TUBB3, BMI-1, MSN, FN1, TrkB, ARHGAP19, LEPR ↓ ↓ ↓ ↓ n/d [138,146,152]
miR-202 FGF2, TIMD4 ↓ ↓ ↓ n/d n/d [25,94]
miR-204 TrkB, FOXC1 ↓ ↓ n/d ↓ n/d [18,30]
miR-206 HDAC6, ERα ↓ ↓ n/d n/d n/d [124,168]
miR-214-3p TWIST1, HMGA1 ↓ ↓ ↓ ↓ ↓ [36,82]
miR-218 ADD2 ↓ ↓ n/d n/d n/d [125]
miR-219-5p COX-2 ↓ n/d n/d n/d n/d [87]
miR-302a-5p HMGA2 ↓ ↓ n/d ↓ n/d [126]
miR-302c-3p ZFX, YKL-40 n/d ↓ n/d n/d n/d [67]
miR-320a eIF4E ↓ ↓ ↓ n/d n/d [103]
miR-326 TWIST1, GPR91 ↓ ↓ ↓ ↓ n/d [55,144]
miR-340-5p eIF4E ↓ n/d ↓ n/d n/d [103]
miR-361 TWIST, STAT3 ↓ ↓ n/d ↓ n/d [41,169]
miR-363 SOX4 ↓ ↓ n/d n/d n/d [83]
miR-365 EZH2, FOS ↓ ↓ ↓ n/d n/d [80]
miR-367-3p HMGA2 ↓ ↓ n/d ↓ n/d [126]
miR-372 RhoC ↓ ↓ n/d ↓ n/d [130]
miR-381 IGF-1R, E2F3 ↓ ↓ n/d n/d n/d [79,148]
miR-424 IGF-1R, E2F6, MMSET ↓ ↓ ↓ n/d n/d [34,58,66]
miR-449a NDRG1, SRC, MET ↓ ↓ n/d ↓ n/d [127,143,147,160,172]
miR-490-3p TGFα, SP1 ↓ ↓ n/d ↓ n/d [64,70]
miR-499a VAV3 n/d n/d n/d ↓ n/d [45]
miR-505 TGFα ↓ ↓ n/d ↓ n/d [131]
miR-513 MMSET n/d ↓ ↓ n/d n/d [34]
miR-543 FAK, TWIST1 ↓ ↓ n/d n/d n/d [20]
miR-545-3p VEGF ↓ ↓ n/d n/d n/d [165]
miR-548c TWIST ↓ ↓ n/d n/d n/d [71]
miR-589-5p TRIP6 ↓ ↓ n/d n/d n/d [86]
miR-646 NPM1 ↓ ↓ n/d n/d n/d [113,155]
miR-873 HDGF n/d ↓ n/d n/d n/d [84]
miR-1271 LDHA, CTNND1 ↓ ↓ n/d n/d n/d [74,88]
miR-1827 TPPP3 ↓ ↓ n/d ↓ n/d [157]
miR-4429 SNHG12 ↓ ↓ n/d n/d n/d [134]
miR-10b HOXB3 ↑ ↑ n/d n/d n/d [129]
miR-21 n/d ↑ ↑ n/d n/d n/d [107]
miR-27a-5p SMAD4 n/d ↑ n/d n/d n/d [135]
miR-93 FOXA1 n/d ↑ ↑ n/d n/d [27]
miR-93-5p ZBTB7A ↑ ↑ n/d n/d n/d [95,105]
miR-103 TIMP3 n/d ↑ n/d n/d n/d [164]
miR-106a BCL2L11 ↑ ↑ n/d ↑ n/d [73]
miR-107-5p ERα ↑ ↑ n/d ↑ n/d [19]
miR-130b * DICER1, BHLHE40/41 n/d ↑ ↑ ↑ n/d [122,171]
miR-135a PTEN ↑ ↑ n/d n/d n/d [159]
miR-146a n/d ↑ ↑ n/d n/d n/d [114]
miR-183 CPEB1, MMP-9, FOXO1 ↑ ↑ ↑ ↑ n/d [62,92,142]
miR-200a FOXA2, PTEN n/d n/d ↑ n/d n/d [102,158]
miR-200c * PTENP1, PTEN, MALAT1 ↑ ↑ ↑ n/d n/d [26,53]
miR-205 ESRRG, PTEN ↑ ↑ ↑ n/d n/d [68,91,149]
miR-210 NFIX ↑ ↑ n/d n/d n/d [100]
miR-216a PD-L1 ↑ ↑ n/d n/d n/d [162]
miR-222-3p ERa n/d ↑ n/d ↑ n/d [52]
miR-301b BHLHE40/41 n/d ↑ ↑ n/d n/d [171]
miR-373 LATS2 ↑ ↑ n/d n/d n/d [49]
miR-423 n/d ↑ ↑ n/d n/d n/d [153]
miR-486-5p MARK1 ↑ ↑ n/d n/d n/d [112]
miR-494-3p PTEN ↑ ↑ n/d ↑ n/d [117]
miR-522 MAOB ↑ ↑ n/d n/d n/d [132]
miR-544a RECK ↑ ↑ n/d ↑ n/d [111]
miR-652 RORA ↑ ↑ n/d n/d ↑ [72]
miR-940 MRVI1 ↑ ↑ n/d n/d n/d [115]
miR-1202 n/d ↑ ↑ n/d n/d n/d [23]

1—direct binding confirmed by luciferase assay, ↓—downregulated in endometrial cancer compared to normal cells, ↑—upregulated in endometrial cancer compared to normal cells, n/d—no data, EMT—epithelial–mesenchymal transition. *—inconsistent data of miRNAs role.