Table 4.
MiRNA | Expression | OS | DFS or PFS | FIGO Stage | Histological Grade | Myometrial Invasion |
Lymph Node Metastases |
Ref. |
---|---|---|---|---|---|---|---|---|
miR-10a | Upregulation | n/d | n/d | n/d | n/d | n/d | ↑ | [29] |
miR-27a | Upregulation | n/d | n/d | ↑ | n/d | n/d | n/d | [60] |
miR-30c-3p | Upregulation | n/d | n/d | n/d | n/d | n/d | ↑a | [178] |
miR-34a * | Upregulation | n/d | n/d | n/d | n/d | n/d | ↑ | [29] |
miR-93-5p | Upregulation | ↓ | n/d | ↑ | n/d | n/d | ↑ | [95] |
miR-95 | Upregulation | ↓ | n/d | ↑ | ↑ | n/d | ↑ | [29,110] |
miR-107-5p | Upregulation | n/d | n/d | ↑ | n/d | ↑ | ↑ | [19] |
miR-130b | Upregulation | ↑ | n/d | ↑ | n/d | ↑ | n/d | [32,122] |
miR-181a | Upregulation | n/d | n/d | ↑ | n/d | n/d | n/d | [37] |
miR-192 | Upregulation | n/d | n/d | n/d | n/d | n/d | ↑a | [178] |
miR-194 | Upregulation | n/d | n/d | n/d | n/d | n/d | ↑a | [178] |
miR-199a | Upregulation | ↑ | ↑ | n/d | n/d | n/d | n/d | [177] |
miR-200a | Upregulation | n/d | n/d | ↑ | n/d | n/d | n/d | [29] |
miR-203 | Upregulation | n/d | n/d | n/d | n/d | n/d | ↑a | [178] |
miR-205 | Upregulation | ↓ | n/d | ↑ | n/d | n/d | n/d | [29] |
miR-210 | Upregulation | n/d | n/d | ↑ | ↑ | n/d | ↑ | [100,178] |
miR-222-3p | Upregulation | n/d | n/d | ↑ | ↑ | n/d | ↑ | [52] |
miR-301 | Upregulation | ↓ | n/d | ↑ | ↑ | ↑ | ↑ | [57,178] |
miR-345 | Upregulation | n/d | n/d | n/d | n/d | n/d | ↑a | [178] |
miR-373 | Upregulation | ↓ | n/d | ↑ | ↑ | ↑ | ↑ | [49,99] |
miR-494-3p | Upregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [117] |
miR-499 | Upregulation | n/d | n/d | ↑ | ↑ | n/d | n/d | [78] |
miR-522 | Upregulation | ↓ | n/d | n/d | ↑ | n/d | n/d | [132] |
miR-544a | Upregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [111] |
miR-940 | Upregulation | ↓ | n/d | n/d | ↑ | n/d | n/d | [115] |
miR-10b | Downregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [38] |
miR-29b | Downregulation | ↓ | ↓ | ↑ | n/d | n/d | ↑ | [24,38,81] |
miR-29a-5p | Downregulation | n/d | n/d | ↑ | ↑ | ↑ | ↑ | [44] |
miR-29c | Downregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [154] |
miR-34a * | Downregulation | ↓ | n/d | ↑ | ↑ | ↑ | ↑ | [34,175] |
miR-34b-5p | Downregulation | n/d | n/d | n/d | n/d | n/d | ↑ | [176] |
miR-34c-3p | Downregulation | n/d | n/d | n/d | n/d | n/d | ↑ | [176] |
miR-34c-5p | Downregulation | n/d | n/d | n/d | n/d | n/d | ↑ | [176] |
miR-100 | Downregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [76] |
miR-101 | Downregulation | ↓ | n/d | n/d | ↑ | ↑ | n/d | [38,56,175] |
miR-124 | Downregulation | ↓ | n/d | ↑ | ↑ | ↑ | ↑ | [99] |
miR-125b | Downregulation | n/d | n/d | n/d | ↑ | ↑ | n/d | [175] |
miR-126 | Downregulation | n/d | n/d | ↑ | ↑ | n/d | n/d | [120] |
miR-139-5p | Downregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [38] |
miR-141 | Downregulation | ↓ | ↓ | n/d | n/d | n/d | n/d | [77] |
miR-142 | Downregulation | ↓ | n/d | n/d | ↑ | ↑ | n/d | [69,175] |
miR-152 | Downregulation | ↓ | ↓ | n/d | n/d | n/d | n/d | [38] |
miR-184 | Downregulation | ↓ | n/d | n/d | n/d | n/d | ↑ | [28,176] |
miR-194 | Downregulation | ↓ | n/d | ↑ | n/d | n/d | n/d | [180] |
miR-195 | Downregulation | n/d | n/d | ↑ | n/d | n/d | ↑a | [108] |
miR-202 | Downregulation | ↓ | n/d | ↑ | n/d | n/d | ↑ | [25] |
miR-203 | Downregulation | ↓ | ↓ | n/d | n/d | n/d | n/d | [77] |
miR-204 | Downregulation | n/d | n/d | ↑ | n/d | n/d | ↑ | [18] |
miR-301b | Downregulation | ↓ | ↓ | n/d | n/d | n/d | n/d | [77] |
miR-361 | Downregulation | n/d | n/d | n/d | ↑ | n/d | n/d | [41] |
miR-372 | Downregulation | n/d | n/d | n/d | n/d | n/d | ↑ | [130] |
miR-375 | Downregulation | n/d | n/d | n/d | n/d | n/d | ↑ | [176] |
miR-381 | Downregulation | n/d | n/d | ↑ | n/d | ↑ | ↑ | [79] |
miR-424 | Downregulation | ↓ | n/d | ↑ | ↑ | n/d | ↑ | [34,58] |
miR-429 | Downregulation | n/d | ↓ | n/d | n/d | n/d | n/d | [77] |
miR-449a | Downregulation | ↓ | n/d | ↑ | ↑ | n/d | ↑ | [147,160] |
miR-455-5p | Downregulation | ↓ | ↓ | n/d | n/d | n/d | n/d | [38] |
miR-490-3p | Downregulation | n/d | n/d | n/d | n/d | ↑ | ↑ | [70] |
miR-497 | Downregulation | ↓ | n/d | ↑ | ↑ | n/d | n/d | [179] |
miR-505 | Downregulation | n/d | n/d | ↑ | n/d | n/d | ↑ | [131] |
miR-513 | Downregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [34] |
miR-548c | Downregulation | ↓ | n/d | n/d | n/d | n/d | n/d | [71] |
miR-873 | Downregulation | n/d | n/d | ↑ | ↑ | n/d | n/d | [84] |
miR-99a | Downregulation | n/d | n/d | ↑ | ↑ | n/d | n/d | [51] |
miR-200 family | Downregulation | n/d | n/d | n/d | ↑ | n/d | n/d | [181] |
miR-1228 | Downregulation | n/d | ↓ | n/d | n/d | n/d | n/d | [77] |
↓—decreased, ↑—increased, n/d—no data, a—lympho-vascular invasion, *—inconsistent data of miRNAs expression and clinical parameters, OS—overall survival, DFS—disease-free survival, PFS—progression-free survival, FIGO stage—The International Federation of Gynecology and Obstetrics staging classification.