. 2021 Jul 3;12(7):1037. doi: 10.3390/genes12071037

Table 1.

Mouse models associated with MOWS-like phenotypes (with Δ = the result of Cre action).

Model	Phenotype Underlying MOWS-Like Defects	Publication
SIP1 fl ox(ex7) SIP1 fl ox(ex7) EIIa-Cre; Zeb2 ^Δex7/Δex7	Early post-gastrulation embryonic lethality, failure of neural tube closure, cranial NCC delamination and migration, and vagal NCC generation, defected somite boundary positioning	Higashi et al., 2002, van de Putte et al., 2003, Maruhashi et al., 2005 [48,53,57]
Zp3-Cre; Zeb2^+/^Δ^ex7;ΔEF1^+/−	Defect in somite production and developmental arrest at E8.5, severe defected dorsal neural tube	Miyoshi et al., 2006 [58]
Emx1-Cre^+/−; Zeb2^KO/ ^Δex7	Lack of hippocampus and corpus callosum	Miquelajauregui et al., 2007 [61]
Wnt1-Cre^+/−; Zeb2^KO/ ^Δex7	Abnormal craniofacial, hearth and melanocyte development and defects in the PNS of the gastrointestinal tract and sympatho-adrenal lineage	van de Putte et al., 2007 [8]
Nestin-Cre^+/−; Zeb2^KO/ ^Δex7	Defects in cortical layering and in interneuron migration	Seuntjens et al., 2009 [47]
Nex-Cre^+/−; Zeb2^KO/ ^Δex7	Defects in cortical layering	Seuntjens et al., 2009 [47]
Nex-Cre^+/−; Zeb2^KO/^Δex7; Ntf3^−/−	Defects in cortical layering	Seuntjens et al., 2009 [47]
Olig1-Cre^+/−; Zeb2^Δex7/Δex7	Defects in the maturation of precursor cells to oligodendrocytes and impaired myelin formation	Weng et al., 2012 [62]
Nkx2.1-Cre^+/−; Zeb2^KO/ ^Δex7	Defects in GABAergic interneuron migration	McKinsey et al., 2013, van den Berghe et al., 2013 [63,64]
Gsh2-Cre^+/−; Zeb2^KO/ ^Δex7	Defects in GABAergic interneuron migration and seizures	van den Berghe et al., 2013 [64]
Dlx5/6-Cre^+/−; Zeb2^KO/ ^Δex7	Defects in GABAergic interneuron migration	van den Berghe et al., 2013 [64]
Zeb2^Δ^ex7/+; pure C57BL/6N	Craniofacial abnormalities, defective corpus callosum formation, decreased numbers of parvalbumin interneurons in the cortex, reduced motor activity, increased anxiety, and impaired sociability	Takagi et al., 2015 [65]
Nex-Cre^+/−; Zeb2^+/^Δ^ex7	Defects in axonal growth and ipsilateral intracortical collateral formation	Srivatsa et al., 2015 [66]
Dhh-Cre^+/−; Zeb2 ^Δex7/Δex7	Arrest of Schwann Cell differentiation during peripheral nerve development and inhibition of remyelination after injury	Wu et al., 2016, Quintes et al., 2016 [67,68]
Dhh-Cre; Zeb2^Δex7/Δex7; Ednrb^Δ^/^Δ Dhh-Cre; Zeb2^Δ^ex7/^Δ^ex7; Hey2^Δ^/^Δ	More mature axon-Schwann Cell units	Quintes et al., 2016 [67]
Nestin-Cre^+/−; Zeb2^KO/ ^Δex7	Increased BMP/Smad dependent axon growth and dopaminergic hyperinnervation in the striatum	Hegarty et al., 2017 [69]
Gsh2-Cre^+/−; Zeb2^KO/ ^Δex7	Defects in differentiation and maturation of olfactory bulb interneurons	Deryckere et al., 2020 [30]
Gfap-Cre^ERT2; Zeb2^Δex7/Δex7	Larger lesions, and delays recovery of motor function after spinal cord injury or ischemic stroke	Vivinetto et al., 2020 [70]
Nex-Cre; Zeb2 ^Δex7/Δex7	Decreased expression of excitatory receptors and an impaired Ca²⁺ signaling	Turovskaya et al., 2020 [71]
Zeb2^+/−; Sox10^+/−	Defects in ENS	Stanchina et al., 2010 [59]
Zeb2^KO/+; Ednrb^s Zeb2^KO/+; Edn3^ls	Severe enteric anomalies and increased neuronal differentiation	Watanabe et al., 2017 [72]
Zeb2^+/KO	Reduced pain response, defects in nociceptive transduction signals	Jeub et al., 2011 [73]
Zeb2^+/KO	Reduced pain response, defects in DRG neuron development	Pradier et al., 2013 [74]
Brn4-Cre^+/−; Zeb2^KO/ ^Δex7	Defects in visceral motor neurons	Roy et al., 2012 [75]
Tyr-Cre; Zeb2 ^Δex7/Δex7	Defects in melanoblast migration and melanocyte differentiation	Denecker et al., 2014 [76]
Pax6(Lens)-Cre; Ze ^Δex7/Δex7 Pax6(LP)-Cre; Zeb2 ^Δex7/Δex7	Defects in vesicle lens closure and defects in lens fiber maturation	Yoshimoto et al., 2005 [77]
MLR10-Cre; Zeb2 ^Δex7/Δex7	Defects in coordinated cell migration, cataract formation and abnormalities in fiber cell organization in the lens	Manthey et al., 2014 [78]
α-Cre; Zeb2^Δex7/Δex7	Defects in cell numbers of various neuronal and glial cell types in the retina	Menuchin-Lasowski et al., 2016 [79]
Six3-Cre; Zeb2 ^Δex7/Δex7	Loss of non-photoreceptor cells, switch in cell fate to photoreceptor cells by retinal progenitors and increased apoptosis	Wei et al., 2019 [80]
Nrc1^iCre; Zeb2 ^Δex7/Δex7	Impaired NK cell maturation, survival and bone marrow exit	Van Helden et al., 2015
Nrc1^iCre; R26-Zeb2^Tg	Decreased NK cells in the bone marrow and an increase in mature NK cells in the spleen and bone marrow	Van Helden et al., 2015 [39]
αMHC-Cre; Zeb2 ^Δex7/Δex7	Impaired cardiac contractility and infarct healing post-myocardial infarction	Gladka et al., 2021 [81]
αMHC-Cre-R26Zeb2^OE	Improved cardiomyocyte survival and cardiac function	Gladka et al., 2021 [81]
Cdh5-Cre^ERT2; Zeb2^Δex7/Δex7	Expanded liver vasculature and irregularities in the angioarchitecture	De Haan et al., 2021 [82]
Cdh5-Cre^ERT2; R26-Zeb2^OE	Reduced vascularity and attenuated CCl₄-induced liver fibrosis	De Haan et al., 2021 [82]
Tyr-Cre^ERT2; Zeb2 ^Δex7/Δex and Tyr-NRAS ^p53	Decreased outgrowth of primary melanomas	Bruneel et al., 2020 [83]
R26-Zeb2^OE/OEiresGFP	Increased proliferation and growth of primary and secondary melanomas	Bruneel et al., 2020 [83]