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. 2021 Jul 20;13(14):3620. doi: 10.3390/cancers13143620

Table 2.

Induction of pyroptosis in cancer by various therapeutic reagents.

Therapeutic Reagents Cancer Type Pathway Refs.
Docosahexaenoic acid (DHA) Breast cancer NF-κB/Caspase-1/GSDMD [81]
α-NETA Ovarian cancer GSDMD/caspase-4 [82]
Polyphyllin VI (PPVI) NSCLC ROS/NF-κB/NLRP3/GSDMD [83]
Metformin ESCC miR-497/PELP1/GSDMD [84]
DPP8/9 AML CARD8/Caspase-1/GSDMD [85]
Cadmium Breast cancer [87]
BI2536 and Cisplatin ESCC [88]
Paclitaxel and cisplatin Lung cancer Caspase-3/GSDME [89]
5-FU Gastric cancer [90]
BRAFi + MEKi Melanoma [91]
Doxorubicin Melanoma eEF-2K/GSDME [92]