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Effect of VPC-2055, EPI-001 and VPC-220010 on the transcriptional activity of (A) full-length AR in an eGFP reporter cell line; (B) ARV7 with a nanoluc reporter cell line; and the proliferation of (C) LNCaP (full length AR); (D) 22rv1 (full length AR and ARV7); and (E) PC-3 (AR null). Viability was calculated following 72 h stimulated by R1881 (DMSO vehicle: LNCaP), or with DMSO alone (22rv1, PC-3). All experiments were done as three biological replicas in triplicate (mean ± SD).
