Figure 4.

Effects of Fx alone and in combination with Dox on the cell viability of MDA-MB-231 MCAs, assessed by the MTT (a) and LDH (b) assays after 96 h of incubation. The percentages of cell viability and LDH release are relative to the control and presented as mean + standard deviation of five independent experiments (each in triplicate). Asterisks indicate significant differences relative to control (* p < 0.05; ** p < 0.01, *** p < 0.001; **** p < 0.0001). Square brackets indicate differences between conditions using t-tests with sequential Holm–Bonferroni corrections.