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. 2021 Jul 16;22(14):7643. doi: 10.3390/ijms22147643

Figure 1.

Figure 1

The STING level of NK cells was significantly decreased in CHB patients. (A) The ratio of peripheral STING+ NK cells (CD3-CD56+, CD3-CD56bright and CD3-CD56dim cells) in CHB patients and HDs. The statistically significant difference between HD and CHB was determined by a two-way ANOVA. (B) STING expression of NK-92 cells were analyzed by flow cytometry, after incubation with serum of HD and CHB patients for 48 h. The serum was diluted with 20 times culture medium of NK-92 cells. (C) STING expression of NK-92 cells were analyzed by flow cytometry after incubation with supernatant of HepG2 and HepG2.2.15 for 48 h. Data are shown as the mean ± SEM. The statistically significant difference between two groups was determined by a t-test. ns, p > 0.05; * p < 0.05; ** p < 0.01. CHB, CHB patients; HD, healthy donors; NK, natural killer.