Table 3.
Pattern of metastases in G12C and non-G12C KRAS positive NSCLC.
| Metastatic Site | G12C KRAS | Non-G12C KRAS | |
|---|---|---|---|
| N = 48 | N = 82 | p-Value | |
| Intrathoracic | 25 | 36 | 0.656 |
| 52% | 44% | ||
| Lung | 18 | 17 | 0.043 |
| 38% | 21% | ||
| Pleural | 10 | 21 | 0.433 |
| 21% | 26% | ||
| Lymphangitic carcinomatosis | 2 | 9 | 0.153 |
| 4% | 11% | ||
| Extrathoracic | 40 | 67 | 0.714 |
| 83% | 82% | ||
| Bone | 22 | 36 | 0.902 |
| 46% | 44% | ||
| Brain | 20 | 29 | 0.717 |
| 42% | 35% | ||
| supratentorial only | 10 (12%) | 11 (8%) | 0.412 |
| infratentorial only | 2 (2%) | 8 (6%) | |
| both supratentorial and infratentorial | 9 (11%) | 10 (8%) | |
| Distant lymph nodes | 5 | 13 | 0.324 |
| 10% | 16% | ||
| Liver | 5 | 5 | 0.448 |
| 10% | 6% | ||
| Adrenal | 10 | 10 | 0.272 |
| 21% | 12% | ||
| Soft tissue | 6 | 8 | 0.735 |
| 13% | 10% |