Table 5.
Imaging features of the primary tumor in G12C KRAS and other targetable genetic alteration-driven NSCLC.
| Imaging Feature | G12C | Fusion Rearrangements | EGFR | G12C vs. Fusion Rearrangements | G12C vs. EGFR |
|---|---|---|---|---|---|
| N = 83 | N = 215 | N = 117 | p Value | p Value | |
| Tumor location | 0.0617 | N/A | |||
| Right upper lobe | 27 (33%) | 46(21%) | |||
| Right middle lobe | 4 (5%) | 26 (12%) | |||
| Right lower lobe | 22 (27%) | 51 (24%) | |||
| Left upper lobe | 14 (17%) | 38 (18%) | |||
| Lingula | 1 (1%) | ||||
| Left lower lobe | 15 (18%) | 54 (25%) | |||
| Multifocal | 17 (21%) | ||||
| Axial location | 0.0192 | 0.0022 | |||
| Inner | 33 (40%) | 115 (53%) | 54 (46%) | ||
| Middle | 4 (5%) | ||||
| Outer | 41 (49%) | 100 (47%) | 75 (35%) | ||
| All | 5 (6%) | 29 (25%) | |||
| Tumor density | 0.0044 | 0.2348 | |||
| Solid | 74 (89%) | 209 (97%) | 104 (89%) | ||
| Ground glass | 2 (2%) | ||||
| Mixed | 7 (8%) | 6 (3%) | 13 (11%) | ||
| Tumor margin | |||||
| Smooth | 47 (57%) | ||||
| Lobulated | 19 (23%) | ||||
| Spiculated | 17 (20%) | ||||
| Air bronchogram | 4 (5%) | 12 (6%) | 28 (28%) | 0.79486 | 0.0001 |
| Cavitation | 11 (13%) | 2 (3%) | 13 (13%) | 0.0051 | 0.6643 |
| Calcification | 3 (4%) | 0 | 1 (1%) | 0.0051 | 0.3092 |