Table 1.

Regulators of mutant p53 function.

Gene Symbol	Function	Effect on p53 in HGSC	Reference
PAX8	Transcription factor	Transcriptionally upregulates GOF p53	[92]
TNFRSF12A	Member of the tumor necrosis factor receptor super-family	Enhances MDM2 mediated ubiquitination and degradation of R248Q mutant p53	[93]
TRIM-71	E3 ubiquitin ligase	Induces degradation of p53 mutants	[94]
USP15	Deubiquitinase	Elevates levels of the aggregated GOF p53 R175H	[95]
MEG3	lncRNA	Upregulates mutant p53 RNA and protein expression levels	[96]
miR let-7d-5p	microRNA	Affects mutant p53 expression in the mRNA and protein level through targeting HMGA	[97]