Table 2.
Downstream targets of p53 in HGSC.
| p53 Downstream Effectors | Regulation by p53 | Biological Effect | Reference |
|---|---|---|---|
| CDKN1A (p21) | Direct transcriptional regulation by mutant p53 | Oncogenic (resulting from an oncogenic role of p21) | [92] |
| PLAC1 | Direct transcriptional de-repression by mutant or null p53 of the inhibitory effect of WT p53 |
Oncogenic function | [107] |
| Notch3 | Transcriptional upregulation by mutp53 | Activates CCNG1 and leads to promoted HGSC metastasis and cisplatin resistance |
[108] |
| Target genes of β-arrestin1/YAP/mutp53 complex | Gene-specific transcriptional regulation |
Enhanced proliferation, survival, and invasion of HGSC in vitro and metastasis in vivo | [109] |
| ACP6 | Downregulation by p53 mutants R175H, R249S and R273H | Increased LPA levels and increased migration and proliferation | [110] |