Table 3.

The role of p53 in the microenvironment.

Pathway	Cell Expressing p53	Biological Effect	Reference
p53	Cancer associated fibroblasts	Changes in the transcriptional signature from a tumor suppressive to a tumor supportive signature	[155]
IL-1β	Cancer associated fibroblasts	Secretion from epithelial cancer cells leads to down regulation of WT p53 in CAFs	[155]
ICAM1	Cancer associated fibroblasts	Knockdown of WT p53 from CAF induces an ICAM1 mediated invasiveness of immortalized epithelial ovarian cells	[156]
MET	Tumor cells	Mutant p53 upregulates Met, that is a receptor to stromal cell derived HGF	[157]
NFκB, TNFα	Tumor cells	loss of p53 in EOC leads to a pro-inflammatory response	[172,173]
Immune activation	Tumor cells	Mutant p53 in HGSC leads to generation of anti p53 auto-antibodies and p53 specific T-cell immunity	[174,175,176,177,178,179,180,181,182,183,184]