Table 4.
Composite disease activity scores and health or quality of life surveys in psoriatic arthritis (PsA) patients at the start of their first biologic or targeted synthetic disease-modifying anti-rheumatic drug (b/tsDMARD) treatment.
| Normal Weight | Overweight | Obese | |||
|---|---|---|---|---|---|
| (n = 325) | (n = 299) | p | (n = 195) | p | |
| MDA | 22 (6.77) | 5 (1.67) | 0.002 | 4 (2.05) | 0.026 |
| Missing | 64 (19.69) | 41 (13.71) | 36 (18.46) | ||
| DAPSA (mean (SD)) | 23.23 (15.46) | 27.03 (17.81) | 0.022 | 26.90 (15.33) | 0.037 |
| Missing | 118 (36.31) | 95 (31.77) | 72 (36.92) | ||
| cDAPSA without CRP (mean (SD)) | 22.16 (14.95) | 25.64 (17.21) | 0.023 | 26.03 (14.89) | 0.020 |
| Missing | 106 (32.62) | 72 (24.08) | 65 (33.33) | ||
| DAS28-ESR (mean (SD)) | 3.30 (1.27) | 3.57 (1.32) | 0.014 | 3.43 (1.23) | 0.273 |
| Missing | 44 (13.54) | 34 (11.37) | 24 (12.31) | ||
| DAS28-CRP (mean (SD)) | 3.26 (1.12) | 3.52 (1.18) | 0.011 | 3.41 (1.09) | 0.191 |
| Missing | 51 (15.69) | 42 (14.05) | 24 (12.31) | ||
| HAQ (mean (SD)) | 0.71 (0.65) | 0.75 (0.58) | 0.375 | 0.89 (0.61) | 0.003 |
| Missing | 53 (16.31) | 46 (15.38) | 38 (19.49) | ||
| Euro-QoL (mean (SD)) | 65.32 (17.81) | 63.51 (17.38) | 0.366 | 60.33 (20.31) | 0.037 |
| Missing | 169 (52.00) | 145 (48.49) | 90 (46.15) | ||
| DLQI (mean (SD)) | 3.53 (5.35) | 4.62 (6.08) | 0.087 | 5.52 (7.66) | 0.013 |
| Missing | 167 (51.38) | 137 (45.82) | 87 (44.62) | ||
| SF12-pcs (mean (SD)) | 39.06 (10.54) | 38.23 (9.94) | 0.368 | 35.78 (9.23) | 0.001 |
| Missing | 67 (20.62) | 64 (21.4) | 41 (21.03) | ||
| SF12-mcs (mean (SD)) | 45.96 (11.36) | 45.48 (11.46) | 0.640 | 44.12 (11.67) | 0.116 |
| Missing | 67 (20.62) | 64 (21.4) | 41 (21.03) |
Values are the number and column percentages, unless otherwise specified. Significance tests compared the overweight and obese categories to the normal weight group using chi-squared test for categorical variables and t-test for continuous variables. For the tests, the missing values did not function as a grouping variable. Abbreviations: n—sample size; SD—standard deviation; MDA—minimal disease activity; DAPSA—Disease Activity Index for Psoriatic Arthritis; DAS28—28-joint Disease Activity Score; ESR—erythrocyte sedimentation rate; CRP—C-reactive protein; HAQ—Health Assessment Questionnaire; Euro-QoL—European Quality of Life instrument; DLQI—Dermatology Life Quality Index; SF12—Short-Form 12 health survey; pcs—physical component summary; mcs—mental component summary.