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Model of PRC1 and PRC2 interactions. (a) PRC1 acts first and induces ubiquitination of H2A. PRC2 is recruited after PRC1, and H3K27me3 is deposited. H2Aub is then removed by UBP12/13 to maintain H3K27me3. (b) PRC2 acts first and deposits H3K27me3; PRC1 is recruited by H3K27me3; and H2A is ubiquitinated afterwards. (c) PRC1 and PRC2 act independently of each other. Both H2A and H2A.Z could be ubiquitinated.
