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. 2021 Jul 14;22(14):7533. doi: 10.3390/ijms22147533

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Model of PRC1 and PRC2 during embryo-to-seedling transition. Recruitment of VAL1/2 to the chromatin of LEC1/LEC2/ABI3/FUS3 or other targets to mediate binding of PRC1 via interaction with the AtBMI1A/B complex. PRC1 ubiquitinates H2A and recruits PRC2 via binding of MSI1 (a PRC2 component) to EMF1/LHP1(PRC1 component), leading to increased levels of H3K27me3 at LEC1/LEC2/ABI3/FUS3 and other genes. UBP12/13 removes ubiquitin from target sites to allow binding of PRC2 and stable silencing.