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. 2021 Jul 14;22(14):7533. doi: 10.3390/ijms22147533

Figure 3.

Figure 3

Model of PRC1 and PRC2 action during juvenile-to-adult vegetative phase change. (a,b) PRC1 and PRC2 during juvenile phase. (a) BRM prevents the formation of nucleosomes near the transition start site (TSS) of MIR156A and possibly prevents binding of PRC2 to MIR156A. PKL binds to MIR156A during juvenile phase and is associated with modulating H3K27ac levels. SWR1 mediates the exchange of H2A to H2A.Z, which works in concert with ATXR7 to deposit H3K4me3. (b) SPL9 and SPL10 are marked by H2Aub that deposited by PRC1 to prevent precocious vegetative phase change. (c,d) PRC1 and PRC2 during adult phase. (c) PKL facilitates nucleosome formation near the TSS and PRC1 and PRC2 are recruited to MIR156A to increase the abundance of H3K27me3 and H2AUb, while the abundance of H3K27ac and H3K4me3 are decreased. VAL1/2 bind to MIR156A to recruit PRC1 and PRC2. (d) PRC1 leaves SPL9/10 to allow for their activation.