Table 1.
Core subunits of PRC1 and PRC2 in different organisms.
| Mammals | Drosophila | Arabidopsis | Characteristic Domain | Activities | |
|---|---|---|---|---|---|
| PRC1 | RING1A/ RING1B |
dRing/ Sce |
AtRING1A/ 1B |
RING finger domain and Ring-finger and WD-40 Associated Ubiquitin-Like (RAWUL) domain | E3 ubiquitin ligase activity for H2A |
| PCGF1-6 | Psc | AtBMI1A/ 1B/1C |
RING finger domain and RAWUL domain | Co-factors for E3 ubiquitin ligase and compact nucleosomes | |
| CBX2/4/6/7/8 | Pc | LHP1(TFL2)/ VRN1 |
Chromodomain and chromo shadow domain | Recognizes and binds to H3K27me3 | |
| PHC1/ PHC2/ PHC3 |
Ph | UNKNOWN | Sterile Alpha Motif (SAM) domain and Zinc Finger domain | Mediates monoubiquitination of histone H2A | |
| PRC2 | EZH1/2 | E(z) | CLF/SWN/ MEA |
SET domain | H3K27 methyltransferase |
| SUZ12 | Su(z)12 | EMF2/VRN2 FIS2 |
Zinc Finger | Assists with E(z) catalytic activity | |
| EED | Esc | FIE | WD-40 repeat domain | Assists with E(z) catalytic activity | |
| RBAP48/46 | P55/Nurf55 | MSI1-5 | WD-40 repeat domain | Histone binding |