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Effect of FMR irradiation after UVB exposure on epidermal cellular senescence. The TUNEL assay shows significantly decreased TUNEL-positive cells after FMR on UVB–irradiated skin. qRT-PCR analyses of premature senescence markers, including p16, p21, p53, MMP-2, and MMP-9 show significant reductions after FMR on UVB-irradiated skin. Statistical analyses were performed via Mann–Whitney U test. * p < 0.05, ** p < 0.01, *** p < 0.005, respectively.
