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. 2021 Jul 2;10(7):1669. doi: 10.3390/cells10071669

Figure 1.

Figure 1

YTHDF1 is upregulated in KRAS/TP53-mutant lung cancer and is indicative of a poor prognosis. (a) Kaplan–Meier survival plots for KRAS/TP53-mut (n = 44), KRAS-mut (n = 64), and TP53-mut (n = 146) groups compared with the wildtype (n = 106) group of the LUAD cohort. (b) Heatmap of mRNA expression of the m6A-related genes in the wildtype (n = 108), KRAS-mut (n = 66), TP53-mut (n = 147), and KRAS/TP53-mut (n = 44) groups of the LUAD cohort. (c) Plot showing the mRNA expression of YTHDF1 in four different mutation groups. (d) Kaplan–Meier survival plots for male LUAD patients stratified by quantile (0.25 and 0.75). The p-values were determined for the Exh result using the log-rank test or Wilcoxon rank-sum test (*** p < 0.001).