Figure 1.

SPINT2 expression in placentas of patients with established placental disease. Compared to preterm controls, SPINT2 mRNA expression (a) was not altered in placentas from normotensive pregnancies affected by foetal growth restriction (FGR), but it was significantly decreased in those from pregnancies compromised by concurrent preeclampsia (PE) and FGR, and increased in preeclamptic placentas of AGA infants. SPINT2 protein expression (b) in these same placentas was also not changed in FGR-affected normotensive pregnancies, but was significantly elevated in all PE cases (with and without FGR). Each data point represents an individual patient sample; data are expressed as median ± IQR; * p < 0.05, ** p < 0.01.