Table 2.
CS tetrasaccharide (CS04) sequences from the library of 192 sequences that satisfied the dual-filter CVLS strategy for TGF-β2.
| Binding Site | Tetrasaccharide Sequence | RMSD (Å) | No of Sulfate | GOLDScore |
|---|---|---|---|---|
| 1 | Zb2B–VbC4B–Zb2B–VbC6B | 1.5 | 4 | 61.7 |
| uAB–VbC4B–Zb2B–VbCB | 1.9 | 2 | 50.3 | |
| ZbB–VbC4B–ZbB–VbCB | 2.3 | 1 | 45.1 | |
| 2 | uAB–VbC6B–Zb2B–VbC46B | 2.5 | 4 | 50.6 |
| VbC6B–ZbB–VbC46B–ZbB | 1.8 | 3 | 53.9 | |
| VbC6B–ZbB–VbC4B–ZbB | 1.3 | 2 | 52.5 | |
| VbCB–Zb2B–VbC6B–Zb2B | 2.0 | 3 | 53.8 | |
| VbCB–ZbB–VbC4B–ZbB | 1.0 | 1 | 48.1 | |
| VbCB–ZbB–VbCB–ZbB | 1.6 | 0 | 46.5 | |
| ZbB–VbC4B–ZbB–VbC4B | 1.7 | 2 | 57.8 |