Table 16.
Comparison of the sensitivity and specificity of virus antigen test in detecting different targets of MERS-CoV and SARS-CoV-2.
| Virus type | Targets/Sources of samples | Sensitivity (SN) | Specificity (SP) | References |
|---|---|---|---|---|
| MERS-CoV | N | +ve results for samples with 10 TCID50/100 μL; | 100% | [179] |
| S | 103.7–104.2 TCID50/mL (81%, ~100 times less sensitive than ELISA) | 100% | [100] | |
| SARS-CoV-2 | N | 98.33% | 98.73% | [257] |
| N | LOD95: 2·07 × 106 and 2·86 × 107 copies/swab | 98.5–100% | [256] | |
| N | 45.4–50.3% | 97.7–97.8% | [250] | |
| N, S | LOD: 0.31–102 TCID50/mL (84–97.7%) (depending on antigen type) | 93.9–100% | [230], [248] | |
| N, E, S, M | LOD: 100,000 RNA copies/mL (78.8%) | 99.7% | [253] | |
| Unclear | 96.52% | 99.68% | [255] | |
| Unclear | 11.1–45.7% (qRT-PCR>virus culture>antigen test) | ~100% (no cross-reactivity with other pathogens) | [249] | |
| Unclear | 81% | 99.1% | [254] | |
| Unclear | 69.86% | 99.61% | [251] | |
| Unclear | 72.5% | 99.4% | [252] | |
| Unclear | 88.9–100% | 46.2–100% | [258] |