Table 18.
Variant of concern (VOC) and variant of interest (VOI) of SARS-CoV-2.
| Variant of concern (VOC) |
Variant of interest (VOI) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variant type | B.1.1.7 (Alpha) | B.1.351 (Beta) | B.1.617.2 (Delta) | P.1 (Gamma) | B.1.427 and B.1.429 (Epsilon) | B.1.525 (Eta) | B.1.526 (Iota) | B.1.617.1 (Kappa) | P.2 (Zeta) |
| Origin | United Kingdom | South Africa | India | Brazil and Japan | California, United States of America | United Kingdom and Nigeria | New York, United States of America | India | Brazil |
| Protein changes/mutations | 69del, 70del, 144del, (E484Ka), (S494Pa), N501Y, A570D, D614G, P681H, T716I, S982A, D1118H (K1191N*) | D80A, D215G, 241del, 242del, 243del, K417N, E484K, N501Y, D614G, A701V | T19R, (G142Da), 156del, 157del, R158G, L452R, T478K, D614G, P681R, D950N | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I | L452R, D614G, S13I, W152C | A67V, 69del, 70del, 144del, E484K, D614G, Q677H, F888L | L5F, (D80Ga), T95I, (Y144-a), (F157Sa), D253G, (L452Ra), (S477Na), E484K, D614G, A701V, (T859Na), (D950Ha), (Q957Ra) | (T95I), G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H | E484K, (F565La), D614G, V1176F |
| Effects on transmissibility | Increased by 50% | Increased by 50% | Increase (% unclear) | Unclear | Increased by 20% | Unclear | Unclear | Unclear | Unclear |
| Reduce neutralization by sera/antibody | Low impact | Significant reduced neutralization | Potential reduced neutralization | Significant reduced neutralization | Moderate reduced neutralization | Potential reduced neutralization | Reduced neutralization | Potential reduced neutralization | Potential reduced neutralization |
| References | [284], [285], [294], [295], [296], [297], [298], [299], [300], [335], [336], [337], [286], [338], [339], [340], [341], [342], [343], [287], [288], [289], [290], [291], [292], [293] | ||||||||
a
Amino acid changes were detected in some of the tested sequences but not all of the tested samples. Till date, there is no any variant that is classified as the variant of high consequence (VOHC). The variant list is not limited to the above variants and the list can be expanding from time to time.