Table 4.
Genotypes and alleles distribution in the case group.
| (a) DIAPH2 PTPRD HIC1. | |||||||||
| CASE | AT | AA | TT | TT | AT | AA | CT | TT | CC |
| Smokers | 21 – 9,3% | 39–17.3% | 166–73.4% | 114–50.4% | 83–36.7% | 29–12.9% | 104–46.0% | 90–39.8% | 32–14.2% |
| Nonsmokers | 2–4.9% | 10–244.4% | 29–70.7% | 19–46.3% | 20–48.8% | 2–4.9% | 19–46.3% | 17–41.5% | 5–12.2% |
| Drinkers | 22–10.7% | 36–17.6% | 147–71.7% | 100–48.8% | 78–38.0% | 27–13.2% | 94–45.8% | 85–41.5% | 26–12.7% |
| Nondrinkers | 1–1.6% | 13–21.3% | 47–77.1% | 33–54.1% | 24–38.3% | 4–6.6% | 28–45.9% | 22–36.1% | 11–18.0% |
| Smokers/Nondrinkers | 1–2.2% | 8–17.3% | 37–80.5% | 23–50.0% | 19–41.3% | 4–8.7% | 23–50.0% | 15–32.6% | 8–17.4% |
| Nonsmokers/Drinkers | 2–7.7% | 5–19.2% | 19–73.1% | 9–34.6% | 15–57.7% | 2–7.7% | 14–53.8% | 10–38.5% | 2–7.7% |
| Smokers/Drinkers | 20–11.1% | 31–17.2% | 129–71.7% | 91–50.5% | 64–35.5% | 25–13.0% | 81–45.0% | 75–41.7% | 24–53.3% |
| Nonsmokers/Nondrinkers | 14–28.6% | 1–2.0% | 34–69.4% | 18–36.7% | 26–53.1% | 5–10.2% | 19–38.8% | 18–36.7% | 12–24.5% |
| (b) DIAPH2 PTPRD HIC1. | |||||||||
| CASE | A | T | ALLELE | T | A | ALLELE | C | T | ALLELE |
| Smokers | 99 | 353 | 452-A (0.22:0.78) | 311 | 141 | 452-A (0.23:0.77) | 168 | 284 | 452-C (0.36:0.64) |
| Nonsmokers | 22 | 60 | 82-A (0.27:0.73) | 58 | 24 | 82-A (0.29:0.71) | 29 | 53 | 82-C (0.35:0.65) |
| Drinkers | 94 | 316 | 410-A (0.23:0.77) | 278 | 132 | 410-A (0.32:0.68) | 146 | 264 | 410-C (0.36:0.64) |
| Nondrinkers | 27 | 95 | 122-A (0.22:0.78) | 90 | 32 | 122-A (0.26:0.74) | 50 | 72 | 122-C (0.41:0.59) |
| Smokers/Nondrinkers | 17 | 75 | 92-A (0.18:0.82) | 65 | 27 | 92-A (0.29:0.71) | 39 | 53 | 92-C (0.42:0.58) |
| Nonsmokers/Drinkers | 12 | 40 | 52-A (0.23:0.77) | 33 | 19 | 52-A (0.37:0.63) | 18 | 34 | 52-C (0.35:0.65) |
| Smokers/Drinkers | 82 | 278 | 360-A (0.23:0.77) | 246 | 114 | 360-A (0.32:0.68) | 129 | 231 | 360-C (0.36:0,64) |
| Nonsmokers/Nondrinkers | 16 | 82 | 98-A (0.16:0.84) | 62 | 36 | 98-A (0.37:0.63) | 43 | 55 | 98-C (0.44:0.56) |
(a) no statistically significant differences in genotypes distribution of subjects between subgroups of cases. (b) significance difference in DIAPH2 (rs6620138) alleles distribution between subgroups smokers and nonsmokers in the case group (chi- square test—p < 0.005), no other.