Table 1.

Expression and secretion co-dependence among ESX-1 effectors.

Effect of EsxA’s Deletion on Other Effectors			Effect of Other Effectors’s Deletion on EsxA
ΔEsxA (48)	CL a	CF b	EsxA	CL a	CF b
EsxB	↓	↓	ΔEsxB [54]	↓	↓
EspB	↓	↓	ΔEspB [54]	↓	↓
EspF	↓	↓	ΔEspE [55]	↑	↑
EspK	↓	↓	ΔEspF [55]	↑	↑
EspJ	↑	↓	ΔEspK [54]	-	↓
PPE68	↓	↓	ΔEspJ [54]	-	↓
			ΔEspI [43]	↓	↓
			ΔEspG1 [43]	↓	↓
			ΔEspH [43]	↓	↓

^a: cell lysate; ^b: culture filtrate; ↓: downregulation; ↑: upregulation; -: unaffected.