Table 1.

Inclusion and exclusion criteria

People were considered as eligible if they meet all of the following criteria	People did not enter the trial if they meet one or more of the following criteria	Participants were excluded during the trial if they meet one or more of the following criteria
BMI greater than or equal to 18.5 kg/m2	A history or current diagnosis of kidney, liver or thyroid disorders, heart diseases, diabetes, different malignancies and other inflammatory comorbidities	Allergic reaction to W-3 or nanocurcumin supplements
Males and females 20–50 years of age	Low BMI (less than 18.5 kg/m2)	Lack of patient's cooperation
Episodic migraine	Dietary supplementation during the preceding three months	Pregnancy during the study period
Stable diet, physical activity or supplements during the trial	Pregnancy, lactation	Self-reported changes in diet and lifestyle
willingness to participate	Menopause	Changes in dosage or type of routine medications
	Alcohol or drug abuse and cigarette smoking during the preceding six months	Over 2 weeks anti-inflammatory drugs consumption
		Compliance rate less than 90%