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. 2021 Jul 23;15:47. doi: 10.1186/s40246-021-00347-y

Fig. 2.

Fig. 2

Characteristics of the spliceopathy samples. a Heat map of the top 50 most differentially abundant exons showing broad clustering by tissue (rectum to the left) but not disease status. The intermediate samples cluster as a group, adjacent to the ileal spliceopathies which are closer to the rectal set and include aspects of both tissues. b Average PSI of exon bins 9 through 14 of CEACAM1, showing average levels of E012 (corresponding to CEACAM1 exon 7) differ by tissue and state. c Gene expression of CEACAM1 by cluster. Intermediate ileum and spliceopathy samples are not significantly different from differentiated ileum, whereas intermediate rectum and differentiated rectum are both significantly elevated relative to ileum. d The proportion of sites with indicated difference in average PSI for comparisons of ileum (n = 50) to rectum (n = 52), spliceopathy ileum (n = 3) to both ileum and to rectum, and intermediate ileum (n = 7) or rectum (n = 7) to corresponding differentiated tissue. The most differential splicing is observed in each bin above 5% for the spliceopathies