Table 1.
Patients’ characteristics of the entire 140 patients with epithelial ovarian cancer, broken down by gBRCA mutation status.
| gBRCA mt (n = 47) | gBRCA VUS (n = 8) | gBRCA wt (n = 85) | p-Value | |
|---|---|---|---|---|
| Age (years), mean (SD) | 54.23 (9.67) | 56.75 (11.71) | 56.19 (13.34) | 0.650 a |
| Ethnicity | ||||
| Caucasians | 47 (100%) | 8 (100%) | 85 (100%) | |
| FIGO Stage, number (%) | 0.339 b | |||
| I | 2 (4.3%) | 1 (12.5%) | 2 (2.4%) | |
| II | 3 (6.4%) | 0 | 1 (1.2%) | |
| III | 34 (72.3%) | 6 (75.0%) | 66 (77.6%) | |
| IV | 8 (17.0%) | 1 (12.5%) | 11 (12.9%) | |
| missing | 0 | 0 | 5 (5.9%) | |
| Grade, number (%) | 0.255 b | |||
| Low-grade | 0 | 0 | 4 (4.7%) | |
| High-grade | 47 (100%) | 8 (100%) | 79 (92.9%) | |
| Missing | 0 | 0 | 2 (2.4%) | |
| Histology, number (%) | 0.064 b | |||
| Serous | 47 (100%) | 8 (100%) | 77 (90.6%) | |
| others | 0 | 0 | 8 (9.4%) | |
| Primary vs. recurrent disease for tumor testing, number (%) | 0.940 b | |||
| Primary disease | 40 (85.1%) | 7 (87.5%) | 71 (83.5%) | |
| Recurrent disease | 7 (14.9%) | 1 (12.5%) | 14 (16.5%) | |
| Family history, number (%) | <0.001 b | |||
| Positive | 16 (34.0%) | 1 (12.5%) | 3 (3.5%) | |
| Negative | 4 (8.5%) | 5 (62.5%) | 30 (35.3%) | |
| Unknown | 27 (57.4%) | 2 (25.0%) | 52 (61.2%) | |
| PFS (months), mean (SD) | 30.06 (25.86) | 30.13 (16.82) | 32.82 (28.42) | 0.843 a |
| OS (months), mean (SD) | 49.17 (44.92) | 41.25 (19.85) | 55.14 (44.82) | 0.579 a |
SD, standard deviation; a one-way ANOVA; b chi-squared test.