Table 2.

Values of the radiomics features of Tumor volume of interest (VOI) in the portal and pre-contrast phases.

Class	Feature	Pre-Contrast Phase (Mean ± SD)	Portal Phase (Mean ± SD)	p	Class	Feature	Pre-Contrast Phase (Mean ± SD)	Portal Phase (Mean ± SD)	p
Conventional (Intensity)	MIN	−73 ± 171	−14 ± 94	<0.001	Gray-Level Run Length Matrices (GLRLM)	GLRLM_SRE	0.87 ± 0.03	0.89 ± 0.03	<0.001
	MEAN	39 ± 30	71 ± 25	<0.001		GLRLM_LRE	1.72 ± 0.28	1.64 ± 0.24	<0.001
	STD. DEVIATION	24 ± 32	22 ± 10	<0.001		GLRLM_LGRE	1.01 × 10−4 ± 7.89 × 10−5	866 × 10−5± 5.02 × 10−6	<0.001
	MAX	127 ± 133	163 ± 100	<0.001		GLRLM_HGRE	10,933.98 ± 515.11	11,619.98 ± 531.51	<0.001
	Q1	26 ± 51	57 ± 24	<0.001		GLRLM_SRLGE	8.90 × 10−5 ± 7.70 × 10−5	7.66 × 10−5± 4.79 × 10−6	<0.001
	Q2	41 ± 22	70 ± 25	<0.001		GLRLM_SRHGE	9558 ± 625	10,297 ± 678	<0.001
	Q3	53 ± 18	85 ± 26	<0.001		GLRLM_LRLGE	1.68 × 10−4 ± 9.21 × 10−5	1.43 × 10−4 ± 2.35 × 10−5	<0.001
First Order	HISTO_Skewness	−0.29 ± 2.08	0.14 ± 1.19	<0.001		GLRLM_LRHGE	18,797 ± 3034	18,998 ± 2652	0.317
	HISTO_Kurtosis	11.16 ± 28.13	5.85 ± 17.82	0.013		GLRLM_GLNU	704 ± 1422	855 ± 1868	0.197
	HISTO_Entropy_log10	0.85 ± 0.14	0.93 ± 0.10	<0.001		GLRLM_RLNU	3500 ± 6687	3696 ± 6933	0.684
	HISTO_Entropy_log2	2.83 ± 0.47	3.08 ± 0.34	<0.001		GLRLM_RP	0.84 ± 0.05	0.85 ± 0.04	<0.001
	HISTO_Energy (=Uniformity)	0.18 ± 0.04	0.14 ± 0.03	<0.001	Gray-Level Zone Length Matrices (GLZLM)	GLZLM_SZE	0.60 ± 0.06	0.58 ± 0.05	<0.001
Gray-Level Colocalization Matrices (GLCM)	GLCM_Homogeneity (=inverse difference)	0.51 ± 0.06	0.49 ± 0.05	<0.001		GLZLM_LZE	12,042 ± 29,885	9120 ± 30,290	0.005
	GLCM_Energy (=Angular second moment)	0.04 ± 0.02	0.03 ± 0.01	<0.001		GLZLM_LGZE	1.14 × 10−4 ± 2.12 × 10−4	8.61 × 10−5 ± 1.53 × 10−5	<0.001
	GLCM_Contrast (=Variance)	18.8 ± 180.71	6.24 ± 6.51	<0.001		GLZLM_HGZE	10,906 ± 763	11,779 ± 539	<0.001
	GLCM_Correlation	0.30 ± 0.15	0.37 ± 0.14	<0.001		GLZLM_SZLGE	7.47 × 10−5 ± 1.97 × 10−4	5.02 × 10−5 ± 1.21 × 10−5	<0.001
	GLCM_Entropy_log10	1.62 ± 0.23	1.73 ± 0.19	<0.001		GLZLM_SZHGE	6519 ± 680	6867 ± 642	<0.001
	GLCM_Entropy_log2(=Joint entropy)	5.37 ± 0.77	5.37 ± 0.77	<0.001		GLZLM_LZLGE	1.11 ± 2.74	0.80 ± 2.64	0.002
	GLCM_Dissimilarity	1.83 ± 2.69	1.78 ± 0.52	<0.001		GLZLM_LZHGE	1.31 × 108 ± 3.26 × 10−8	1.04 × 108 ± 3.49 × 10−8	0.011
NGLDM	NGLDM_Coarseness	8.47 ± 1.14	1.00 ± 1.49	0.350		GLZLM_GLNU	112.06 ± 63	58 ± 82.71	0.473
	NGLDM_Contrast	0.06 ± 0.11	0.06 ± 0.03	<0.001		GLZLM_ZLNU	218 ± 403	211 ± 336	0.783
	NGLDM_Busyness	0.34 ± 0.54	0.29 ± 0.46	0.266		GLZLM_ZP	0.14 ± 0.08	0.16 ± 0.08	0.004

SD: Standard deviation; Q1–3: Quartiles; NGLDM: Neighboring gray-level difference matrices; SRE/LRE/LGRE/HGRE: Short/long/high-gray/low-gray run emphasis; GL/RLNU: Gray-level/run length non-uniformity RP: Run percentage; SZE/LZE/LGZE/HGZE: Short/long/high-gray/low-gray zone emphasis; GL/ZLNU: Gray-level/zone length non-uniformity; ZP: Zone percentage.