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Cellular protein degradation pathways and chemical-mediated targeted protein degradation methods. Ub, ubiquitin; UPS, ubiquitin–proteasome system; LC3, Microtubule-associated proteins 1A/1B light chain 3B; AUTAC, autophagy-targeting chimeras; ATTEC, autophagosome-tethering compound; LYTAC, lysosome-targeting chimaeras; Cl-M6PR, cation-independent mannose 6-phosphate receptor; POI, protein of interest; E3, E3 ubiquitin ligase; PROTAC, proteolysis-targeting chimera.
