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. 2021 Jul 16;22(14):7626. doi: 10.3390/ijms22147626

Figure 6.

Figure 6

The effect of complexes 1–5 on the activity of transcription factors NF-κB and AP-1. THP-1-XBlueTM-MD2-CD14 cells were pre-treated by the complexes, pomiferin (Pom.) or prednisone (Pred.) dissolved in 0.1% DMF at indicated concentrations for 1 h. Then, lipopolysaccharide (LPS) was added to trigger the NF-κB/AP-1 activation. The activity of NF-κB/AP-1 was determined using QuantiBlue™ assay 24 h after LPS stimulation. Graph represents mean values of three determinations ± SEM. The dotted line shows the value of 0.1% DMF treated group. * indicates statistical significance (p ≤ 0.05) to 0.1% DMF treated group; ** indicates statistical significance (p ≤ 0.01) to 0.1% DMF treated group; **** indicates statistical significance (p ≤ 0.0001) to 0.1% DMF treated group.