Skip to main content
. 2021 Jul 16;22(14):7626. doi: 10.3390/ijms22147626

Figure 8.

Figure 8

The effect of complexes 2, 4 and 5 on the secretion of TNF-α. THP-1 cells were differentiated to macrophages by PMA. Such cells were pre-treated by complexes 2, 4, and 5 (200 nM) or prednisone (200 nM) for 1 h, then LPS (1 µg/mL) was added to trigger the inflammatory signalization. Cultivation medium was collected 24 h after LPS stimulation and the amount of TNF-α was determined by ELISA technique. Graph represents mean ± SEM. *** indicates statistical significance (p ≤ 0.001) to 0.1% DMF-treated group. **** indicates statistical significance (p ≤ 0.0001) to 0.1% DMF-treated group.