Table 3.

Physicochemical parameters of the ligands.

Ligand	Mol wt.	No. of HBA	No. of HBD	MolLogP	MolPSA
Kurchessine	372.35	2	0	6.10	5.76 Å2
Conessine	356.32	2	0	5.16	6.03 Å2
Isoconessimine	342.30	2	1	4.61	15.09 Å2
Pubescine	382.19	5	1	2.28	50.49 Å2
Holadienine	325.24	2	0	4.25	16.93 Å2
Holanamine	325.20	3	1	3.37	39.05 Å2
Conessimine	342.30	2	1	4.67	14.99 Å2
Holadysenterine	390.29	4	4	2.59	74.72 Å2
Kurchine	342.30	2	1	4.61	15.09 Å2
Loperamide	476.22	3	1	5.39	34.51 Å2