Table 4.
ADMET Properties of the Ligands.
| Ligand | Blood Brain Barrier | Caco-2 Permeability | Human Intestinal Absorption | P-Glycoprotein Substrate |
|---|---|---|---|---|
| Kurchessine | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |
| Conessine | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |
| Isoconessimine | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |
| Pubescine | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |
| Holadienine | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |
| Holanamine | BBB+ | Caco2+ | HIA+ | Substrate, Non-inhibitor |
| Conessimine | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |
| Holadysenterine | BBB+ | Caco2- | HIA+ | Substrate, Non-inhibitor |
| Kurchine | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |
| Loperamide | BBB+ | Caco2+ | HIA+ | Substrate, Inhibitor |