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NETs in ANCA-associated vasculitis. (Left): Cross-section of a small vessel. (Right): Pathogenesis of ANCA-associated vasculitis is multifactorial, involving numerous immune cells. B lymphocytes feature prominently as producers of ANCAs, while activated neutrophils undergo NETs formation driving tissue damage via injury to the vascular endothelium (made with biorender.com, accessed on 4 June 2001).
