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. 2021 Jul 19;22(14):7680. doi: 10.3390/ijms22147680

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of metformin on myocardial lipids, lipotoxic intermediates (A) triglycerides, (B) diacylglycerols, (C) cholesteryl esters, (D) lysophosphatidylcholine) and CYP-derived arachidonic acid metabolites (E) 14,15-epoxyeicosatrienoic acid, (F) 20-hydroxyeicosatetraenoic acid) in Wistar control (W) and hereditary hypertriglyceridemic (HHTg) rats. Data are mean ± SEM; n = 8 for each group. Significance was determined using two-way ANOVA and Fisher’s LSD post-hoc test (* denotes p < 0.05; ** denotes p < 0.01; *** denotes p < 0.001).