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. 2021 Jul 16;22(14):7646. doi: 10.3390/ijms22147646

Figure 3.

Figure 3

COPD-derived SAECs are characterized by a pro-inflammatory gene expression profile. (a) GSEA on the genes up-regulated in COPD compared to HC in at least one cell type. Selected significantly (adj. p < 0.05) enriched molecular processes are shown for air control and smoke-exposed cells. (b) Protein–protein interaction network of pro-inflammatory and anti-microbial genes that are increased in air control and/or smoke-exposed cells of COPD donors. (c) Relative expression of the gene set from (b) and de-regulated mucin encoding genes across the main SAEC populations from HC- and COPD-derived air control and smoke-exposed ALI cultures. (d) Violin plots illustrate MUC5AC expression across the main cell types in air control and smoke-exposed SAECs from COPD and HC donors. (e) Representative immunofluorescence labelling of MUC5AC in air control and smoke-exposed SAEC sections from HC and COPD donors. *: pathway not significantly enriched (adj. p > 0.05).