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Smoke exposure affects the expression of SARS-CoV-2 entry factors in SAEC populations. (a) Dot plot illustrating the average relative expression and fraction of cells that express genes encoding for SARS-CoV-2 entry factors across the main SAEC populations. (b,c) Smoke induced shifts of ACE2+ cell frequency in SAEC ALI cultures from HC and COPD donors (n = 3, each). Effects are shown for acute (b) and chronic (c) smoke exposure.
