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. 2021 Jul 24;21:289. doi: 10.1186/s12883-021-02325-2

Table 4.

Sensitivity and specificity (%) vs CH for different MTA score thresholds

MTA cut-off Sensitivity Specificity
AD SVD Mixed
 ≤ 74 years
N 77 19 26 99
 0.5 96.1 89.5 92.3 36.4
 1.0 81.8 84.2 80.8 67.7
 1.5 66.2 47.4 53.8 97.0
 2.0 48.1 26.3 42.3 100
 ≥ 75 years
N 21 6 25 6
 0.5 95.2 83.3 100 0
 1.0 90.5 66.7 88.0 16.7
 1.5 76.2 50.0 72.0 66.7
 2.0 61.9 16.7 48.0 100

MTA cut-off indicates lowest pathological mean MTA score (average right + left)

Dementia subtypes other than AD, vascular dementia and mixed dementia not shown (n (≤ 74 years) = 33, n (≥ 75 years) = 7)

AD Alzheimer’s disease, CH Cognitively healthy, Mixed Mixed dementia, MTA Medial temporal lobe atrophy, SVD Subcortical vascular dementia