. 2021 Jul 18;13(14):3594. doi: 10.3390/cancers13143594

Table 5.

Univariable and multivariable analysis for overall survival.

Characteristics		Univariable Analysis			Multivariable Analysis
Characteristics		5-Years OS (%)	Median OS (Months)	p Values	HR	95% C.I.	p Values
Age, years	<70	41.9	49.4	0.081
	≥70	27.4	38.7	0.081
Gender	M	30.3	43.9	0.120
	F	43.3	51.3	0.120
Type of BTC	ICC	42.7	50.1	<0.001	ref		0.002
	PCC	31.8	41.8		1.512	1.016–2.295	0.048
	DCC	37.2	31.2		0.935	0.461–1.895	0.935
	GBC	20.7	18.6		2.698	1.580–4.606	<0.001
Preoperative ChT	No	35.5	43.1	0.793
	Yes	38.1	46.5	0.793
AJCC 8th T Stage	T1–2	48.1	55.7	<0.001	1.515	1.076–2.352	0.014
	T3–4	23.8	30.4	<0.001	1.515	1.076–2.352	0.014
AJCC 8th N Stage	N0	53.4	64.9	<0.001	2.431	1.613–3.664	<0.001
	N1–N2	12.8	26.3	<0.001	2.431	1.613–3.664	<0.001
Histologic grading	G1–2	36.9	48.5	0.002	1.494	1.008–2.213	0.045
	G3–4	28.5	26.9	0.002	1.494	1.008–2.213	0.045
Radicality	R0	38.2	48.8	0.006	1.108	0.746–1.647	0.611
	R1	32.1	32.8	0.006	1.108	0.746–1.647	0.611
Macrovascular invasion	No	39.0	48.8	<0.001	1.335	0.894–1.991	0.157
Macrovascular invasion	Yes	27.4	26.6	<0.001	1.335	0.894–1.991	0.157
Postoperative ChT	No	35.0	43.1	0.654
Postoperative ChT	Yes	37.3	48.1	0.654
LMR	≥3.47	39.6	48.8	0.004	1.378	1.046–2.007	0.025
	<3.47	33.2	32.8	0.004	1.378	1.046–2.007	0.025

BTC, biliary tract cancer; ChT, chemotherapy; AJCC, American Joint Committee against Cancer; PBD, preoperative biliary drainage; LMR, lymphocyte to monocyte ratio.