Fig. 6.

Cardiac function studies in mice treated with saline solution (Sham), EMPA 10 mg/kg/day, DOXO 2.17 mg/kg/day or EMPA plus DOXO (n = 6 for each group). Cardiac function parameters IVS;d-D (mm), LVID;d-D (mm), LVID;s-D (mm), LVPW;d-D (mm), EF (%), FS (%), LV Mass (mg), LV Vol; d (µl), LV Vol; s (µl) were determined through non-invasive transthoracic echocardiography Vevo 2100. (two-way ANOVA with a Bonferroni post hoc test). Values are expressed ± SD. *** P < 0.001; **P < 0.01; * P < 0.05; ns: not significant