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. 2021 Jul 15;22(14):7579. doi: 10.3390/ijms22147579

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Expression of complement genes in iPSC-derived neural progenitor cells, neurons and astrocytes. Relative transcript levels of key complement system components, receptors, and regulators measured by RT-qPCR in: (A) iPSC-derived NPCs of control (n = 4) and ASD (n = 7) subjects; (B) iPSC-derived neurons of control (n = 3) and ASD (n = 5) subjects; (C) iPSC-derived astrocytes of control (n = 4) and ASD (n = 5) subjects. A significant decrease in the expression levels of C4A/B and SERPING1 mRNAs was observed in astrocytes derived from individuals with ASD compared to control astrocytes. ** p < 0.01.

Expression of complement genes in iPSC-derived neural progenitor cells, neurons and astrocytes. Relative transcript levels of key complement system components, receptors, and regulators measured by RT-qPCR in: (A) iPSC-derived NPCs of control (n = 4) and ASD (n = 7) subjects; (B) iPSC-derived neurons of control (n = 3) and ASD (n = 5) subjects; (C) iPSC-derived astrocytes of control (n = 4) and ASD (n = 5) subjects. A significant decrease in the expression levels of C4A/B and SERPING1 mRNAs was observed in astrocytes derived from individuals with ASD compared to control astrocytes. ** p < 0.01.