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. 2021 Jul 15;22(14):7579. doi: 10.3390/ijms22147579

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Secretion of complement proteins by iPSC-derived neural progenitor cells, neurons and astrocytes. Protein levels (pg/mL) of complement components and regulators measured by multiplex assays in culture supernatants from (A) iPSC-derived NPCs of control (n = 4) and ASD (n = 5) subjects; (B) iPSC-derived neurons of control (n = 4) and ASD (n = 5) subjects; (C) iPSC-derived astrocytes of control (n = 2) and ASD (n = 4) subjects. (D) Protein levels of C4 in culture supernatants of iPSC-derived astrocytes of control (n = 4) and ASD (n = 4) subjects were also assessed by using an ELISA assay. A significant decrease in the secretion levels of C4 was observed in astrocytes derived from individuals with ASD compared to control astrocytes. *** p < 0.001.

Secretion of complement proteins by iPSC-derived neural progenitor cells, neurons and astrocytes. Protein levels (pg/mL) of complement components and regulators measured by multiplex assays in culture supernatants from (A) iPSC-derived NPCs of control (n = 4) and ASD (n = 5) subjects; (B) iPSC-derived neurons of control (n = 4) and ASD (n = 5) subjects; (C) iPSC-derived astrocytes of control (n = 2) and ASD (n = 4) subjects. (D) Protein levels of C4 in culture supernatants of iPSC-derived astrocytes of control (n = 4) and ASD (n = 4) subjects were also assessed by using an ELISA assay. A significant decrease in the secretion levels of C4 was observed in astrocytes derived from individuals with ASD compared to control astrocytes. *** p < 0.001.